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NFL Week 10 Predictions: Key Matchups and Playoff Implications

As the 2025 NFL season enters Week 10, teams are intensifying their playoff pursuits. With some franchises striving to recover from earlier setbacks, others are already contemplating the next season. This week features an international game in Berlin, Germany, and includes a bye week for four teams: the Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, and Tennessee Titans.

For fans of the Miami Dolphins, anticipation surrounds the team’s second meeting this season against the Buffalo Bills. Currently holding a record of 6-2, Buffalo has shown dominance, while Miami’s struggles are evident with a record of 2-7. Despite the odds heavily favoring Buffalo by 9.5 points, the Dolphins hope to turn the tables.

Week 10 Matchups and Odds

The Sunday schedule showcases a mix of intriguing matchups, with several games set to kick off early. Notably, the international game will feature the Atlanta Falcons taking on the Indianapolis Colts at 9:30 a.m. Eastern Time.

Here is the complete list of Sunday’s games and their respective odds from FanDuel Sportsbook:

– 9:30 a.m. Eastern
Atlanta Falcons vs. (-6.5) Indianapolis Colts – Berlin, Germany
– 1:00 p.m. Eastern
New Orleans Saints at (-5.5) Carolina Panthers
New York Giants at (-4.5) Chicago Bears
Jacksonville Jaguars (-1.5) at Houston Texans
Buffalo Bills (-9.5) at Miami Dolphins
Baltimore Ravens (-4.5) at Minnesota Vikings
Cleveland Browns (-2.5) at New York Jets
New England Patriots at (-2.5) Tampa Bay Buccaneers
– 4:05 p.m. Eastern
Arizona Cardinals at (-7) Seattle Seahawks
– 4:25 p.m. Eastern
Los Angeles Rams (-5.5) at San Francisco 49ers
Detroit Lions (-7.5) at Washington Commanders
– 8:20 p.m. Eastern
Pittsburgh Steelers at (-2.5) Los Angeles Chargers

As the action unfolds this weekend, contributors will share their predictions for all games, tracking their straight-up picks throughout the season. Notable contributors include Sumeet Jena, who leads the current standings with a record of 91-44-1, followed by James McKinney at 88-47-1 and Kevin Nogle at 87-48-1.

Fans can also engage in making their predictions through Tallysight, which offers a new community picks option.

As teams position themselves for the playoff race, Week 10 promises exciting matchups and potential upsets, particularly for the Dolphins as they seek to defy expectations against the formidable Bills.

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