The San Francisco 49ers are grappling with a significant setback as quarterback Brock Purdy faces the possibility of missing multiple games due to injuries. Head Coach Kyle Shanahan confirmed on September 10, 2025, that Purdy is dealing with both left shoulder and toe injuries, making him a “long shot” to participate in the upcoming game against the New Orleans Saints on Sunday at 1 p.m. ET.
In Purdy’s absence, the 49ers are expected to rely on backup quarterback Mac Jones, who will take the helm in a challenging situation. The team has already suffered significant injuries this season, with six-time Pro Bowler George Kittle now placed on injured reserve due to a hamstring issue. Kittle will miss at least the next four games, further diminishing the options available to San Francisco’s offense.
The 49ers’ offensive struggles are compounded by the absence of Brandon Aiyuk, who is not anticipated to return until Week 6 because of a knee injury. With key players sidelined, Jones, who previously struggled with the New England Patriots and had a rough tenure with the Jacksonville Jaguars, will need to find a way to stabilize the team. Last season, Jones started seven games, finishing with a 2-5 record, throwing eight touchdowns and eight interceptions, and posting a below-average QBR of 36.6.
Jones’s potential to perform better in a system that aligns with his skills could offer a glimmer of hope. Shanahan noted in August 2022 that the 49ers nearly selected Jones instead of Trey Lance with the third overall pick in the 2021 NFL Draft. Nonetheless, Jones represents a significant downgrade from Purdy, who played a pivotal role in leading the 49ers to Super Bowl LVIII during the 2023 season. In that season, Purdy ranked 10th in the NFL with 3,864 passing yards over 15 games and achieved a QBR of 64.8.
Purdy’s performance in the season opener against the Seattle Seahawks showcased his ability to make crucial plays, including a game-winning touchdown pass to rookie tight end Jake Tonges. This pass, with a completion probability of just 14.7%, was deemed the most improbable completion of the week leading into Sunday Night Football.
As the 49ers prepare for their matchup against the Saints, the defensive unit, which limited Seattle to 230 yards in their Week 1 victory, will need to step up. With the offense facing uncertainty and injuries, the defense’s performance becomes increasingly critical for the team’s success in the coming weeks. The 49ers and their fans will be hoping for a swift recovery for Purdy, as his absence could significantly impact the team’s aspirations this season.
